Suplemen magnesium dapat menyebabkan diare, mual, dan kram perut. Orang dengan gangguan ginjal lebih berisiko mengalami penumpukan magnesium karena tubuhnya tidak dapat membuang kelebihan mineral tersebut dengan baik.
Magnesium juga dapat mengganggu penyerapan beberapa antibiotik dan obat osteoporosis. Konsultasikan dengan dokter atau apoteker jika sedang mengonsumsi obat rutin.
Jangan menggunakan magnesium untuk menutupi masalah tidur yang terus berulang. Sulit tidur dapat disebabkan oleh kecemasan, depresi, sleep apnea, restless legs syndrome, kafein, efek obat, nyeri kronis, atau jadwal tidur yang tidak teratur.
Untuk insomnia kronis, terapi perilaku kognitif untuk insomnia atau CBT-I tetap menjadi terapi lini pertama. Magnesium hanya dapat dipertimbangkan sebagai pendamping, bukan pengganti pemeriksaan dan penanganan penyebab gangguan tidur.
Referensi
Amin Arab, Nasrin Rafie, Reza Amani, dan Fatemeh Shirani, “The Role of Magnesium in Sleep Health: A Systematic Review of Available Literature,” Biological Trace Element Research 201, no. 1 (2023): 121–128, https://doi.org/10.1007/s12011-022-03162-1.
Julius Schuster, Igor Cycelskij, Adrian Lopresti, dan Andreas Hahn, “Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized, Placebo-Controlled Trial,” Nature and Science of Sleep 17 (2025): 2027–2040, https://doi.org/10.2147/NSS.S524348.
Heather A. Hausenblas et al., “Magnesium-L-Threonate Improves Sleep Quality and Daytime Functioning in Adults with Self-Reported Sleep Problems: A Randomized Controlled Trial,” Sleep Medicine: X 8 (2024): 100121, https://doi.org/10.1016/j.sleepx.2024.100121.
Adrian L. Lopresti dan Stephen J. Smith, “The Effects of Magnesium L-Threonate (Magtein®) on Cognitive Performance and Sleep Quality in Adults: A Randomised, Double-Blind, Placebo-Controlled Trial,” Frontiers in Nutrition 12 (2026): 1729164, https://doi.org/10.3389/fnut.2025.1729164.
National Institutes of Health, Office of Dietary Supplements, “Magnesium: Fact Sheet for Health Professionals,” diakses Juli 2026.
Jasmine Mah dan Tyler Pitre, “Oral Magnesium Supplementation for Insomnia in Older Adults: A Systematic Review and Meta-Analysis,” BMC Complementary Medicine and Therapies 21 (2021): 125, https://doi.org/10.1186/s12906-021-03297-z.
Behnood Abbasi et al., “The Effect of Magnesium Supplementation on Primary Insomnia in Elderly: A Double-Blind Placebo-Controlled Clinical Trial,” Journal of Research in Medical Sciences 17, no. 12 (2012): 1161–1169, https://pmc.ncbi.nlm.nih.gov/articles/PMC3703169/.
Jack D. Edinger et al., “Behavioral and Psychological Treatments for Chronic Insomnia Disorder in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline,” Journal of Clinical Sleep Medicine 17, no. 2 (2021): 255–262, https://doi.org/10.5664/jcsm.8986.